individualHealthcare / Reproductive MedicineGlobal / Not Specified

Patients with Asthenozoospermia

Individuals experiencing reduced or absent sperm motility, a primary factor in human male infertility.

Cavarocchi et al., 2025 — "Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies," Andrology, Wiley Online Library

Patients with asthenozoospermia are men who exhibit a reduction or absence of sperm motility, which hinders the ability of sperm to swim through the female reproductive tract to fertilize an egg. This condition can occur in isolation or alongside other sperm abnormalities and is a severe contributor to 50% of male infertility cases.

Ideas that could help Patients with Asthenozoospermia

TEX44-Based Male Infertility Diagnostic Panel
A targeted genetic screening test for patients with asthenozoospermia to identify biallelic TEX44 variants and associated mitochondrial sheath defects. The panel aims to differentiate metabolic mitochondrial failures from other structural axonemal defects.
Why it helps: Provides a clear genetic explanation for their condition, which can inform expectations and potential targeted treatment paths.