SWOT Analysis: Allele-Drift Watch: HLA Release Impact Monitor for Donor Registries

A service that ingests each IPD-IMGT/HLA database release and tells stem-cell registries exactly which stored donor typings changed meaning — new ambiguity, new matches, shifted match grades — so staff re-verify only the affected records instead of auditing the whole registry. New evidence that registries are now typing donors at full-gene resolution at scale strengthens the case: legacy ambiguous records are where releases resolve or shift calls, while newer genomic-resolution records are where newly named alleles change interpretations outright. The prioritized worklist now also recommends which flagged donors warrant batch confirmatory re-typing, since high-throughput NGS has made that affordable.