← Back to the idea

Cell-Permeable Intracellular 5-HT2AR Agonist for Cortical Neuroplasticity

Develop membrane-permeable compounds that selectively activate the intracellular pool of 5-HT2A receptors in cortical neurons to restore dendritic spine density—achieving the plasticity benefit of psychedelics without engaging surface receptors linked to hallucinogenic signaling.