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Non-Hallucinogenic TrkB Positive Allosteric Modulator (PAM) Antidepressant

A small-molecule drug designed to trigger rapid antidepressant effects by acting as a positive allosteric modulator of the TrkB receptor. By targeting the transmembrane domain of TrkB without activating 5-HT2A receptors, the drug aims to provide the neuroplasticity benefits of psychedelics without inducing hallucinations.