Mayo Clinic
World-renowned not-for-profit integrated multispecialty medical center and health system
Mayo Clinic — About Mayo Clinic (Official Site)Mayo Clinic is a not-for-profit healthcare organization founded more than a century ago by the Mayo brothers, the Sisters of St. Francis, and their colleagues. It pioneered the integrated, multispecialty group practice of medicine — the first of its kind in the world — and in 1919 was formally established as a not-for-profit through a landmark donation of the founders' assets and life savings. Its mission is to inspire hope and contribute to health and well-being by providing the best care to every patient.
Mayo Clinic operates three major campuses in Rochester, Minnesota; Jacksonville, Florida; and Phoenix/Scottsdale, Arizona, as well as the Mayo Clinic Health System, a network of community-based clinics and hospitals. It employs over 7,300 physicians and scientists alongside roughly 66,000 administrative and allied health staff, with total workforce reaching nearly 83,000 as of 2024. In that year, it cared for patients from every U.S. state and 135 countries, recorded $19.79 billion in revenue with a record $1.3 billion operating margin, and more than doubled its patient charity care spending to $130 million.
Mayo Clinic is top-ranked in more specialties than any other hospital by both Newsweek and U.S. News & World Report, and has appeared on the U.S. News Honor Roll since its first publication in 1990. Its research legacy includes breakthroughs such as real-time frozen-section tumor analysis, the discovery of cortisone, and the first successful surgeries using a heart-lung bypass machine. It also houses the Mayo Clinic Alix School of Medicine, opened in 1972.
As one of the world's leading academic medical centers, Mayo Clinic is a highly relevant target for innovations in clinical care delivery, medical research, health system management, patient experience, and healthcare technology — given its scale, global patient reach, and continuous investment in advancing medicine.
Ideas that could help Mayo Clinic
- Perioperative UDCA Prophylaxis Kit
A targeted supplementation protocol using ursodeoxycholic acid (UDCA) administered to patients immediately before and after renal surgery to prevent ischemia-reperfusion injury.
Why it helps: As a leading surgical center, they can implement standardized protocols to reduce post-operative renal complications in transplant or nephrectomy patients.
- Mutation-Risk Predictive Oncology Tool
A clinical decision support tool that predicts the window of time when a tumor is most likely to develop drug resistance based on its mutation rate.
Why it helps: As a leading research hospital, they can integrate predictive mutation modeling into personalized cancer treatment plans for patients.
- SLC25A45-Based GLP-1RA Response Diagnostic
A diagnostic test to identify patients who are likely to be resistant to GLP-1 receptor agonist (GLP-1RA) weight-loss drugs based on SLC25A45 genetic variants or expression levels.
Why it helps: Clinicians can use the test to explain why certain patients fail to lose weight on GLP-1RAs and pivot to alternative metabolic interventions.
- Intracellular 5-HT2A Plasticity Agonists
A new class of neuroplasticity-promoting drugs that specifically target intracellular 5-HT2A receptors to treat neuropsychiatric diseases without triggering standard surface-receptor signaling.
Why it helps: Clinicians treating complex neuropsychiatric diseases would benefit from a drug that restores cortical plasticity without the side effects of traditional agonists.